2-hydroxyethylphosphonate dioxygenase - definizione. Che cos'è 2-hydroxyethylphosphonate dioxygenase
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Cosa (chi) è 2-hydroxyethylphosphonate dioxygenase - definizione


2-hydroxyethylphosphonate dioxygenase         
2-hydroxyethylphosphonate dioxygenase (, HEPD, phpD (gene)) is an enzyme with systematic name 2-hydroxyethylphosphonate:O2 1,2-oxidoreductase (hydroxymethylphosphonate forming). This enzyme catalyses the following chemical reaction
Alpha-ketoglutarate-dependent hydroxylases         
  • Common inhibitors of αKG-dependent dioxygenases. They compete against the cosubstrate αKG for binding to the active site Fe(II).
  • Consensus catalytic mechanism of the αKG-dependent dioxygenase superfamily.
  • prolyl hydroxylase isoform 2]] (PHD2), a human αKG-dependent dioxygenase. The Fe(II) is coordinated by two imidazoles and one carboxylate provided by the protein.  Other ligands on iron, which are transiently occupied αKG and O<sub>2</sub>, are omitted for clarity.
CLASS OF ENZYMES
2-oxoglutarate (2OG)-dependent dioxygenases; Alpha-ketoglutarate-dependent hydroxylase; 2-oxoglutarate–dependent dioxygenase; 2-oxoglutarate-dependent dioxygenase
Alpha-ketoglutarate-dependent hydroxylases are a major class of non-heme iron proteins that catalyse a wide range of reactions. These reactions include hydroxylation reactions, demethylations, ring expansions, ring closures, and desaturations.
Lysyl hydroxylase         
CLASS OF ENZYMES
Procollagen-lysine 5-dioxygenase; Procollagen-lysine, 2-oxoglutarate 5-dioxygenase; Lysyl 5-hydroxylase; PLOD1; EC 1.14.11.4; L-lysine-(procollagen),2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)
Lysyl hydroxylases (or procollagen-lysine 5-dioxygenases) are alpha-ketoglutarate-dependent hydroxylases enzymes that catalyze the hydroxylation of lysine to hydroxylysine. Lysyl hydroxylases require iron and vitamin C as cofactors for their oxidation activity.